Improved One-Pot Synthesis of Citalopram Diol and Its Conversion to Citalopram

An improved process is developed for the preparation of citalopram diol, 2 which involves two consecutive Grignard reactions in situ followed by an efficient and simple workup process with improved overall yield. Process development efforts for conversion of 2 into citalopram, 1, and a control strat...

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Veröffentlicht in:	Organic process research & development 2013-05, Vol.17 (5), p.798-805
Hauptverfasser:	Vedantham, Ravindra, Vetukuri, VNKV Prasada Raju, Boini, Ambaiah, Khagga, Mukkanti, Bandichhor, Rakeshwar
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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