Scale-Up Synthesis of a TRPV1 Antagonist Featuring a Facile Thiazolo[5,4-d]pyrimidine Formation

An efficient and practical synthesis of a TRPV1 inhibitor bearing a thiazolo[5,4-d]pyrimidine core was developed. The initial synthesis was modified to facilitate acylation of 5-aminopyrimidine and subsequent thiazole formation. The synthesis features an efficient two-pot, five-step process for the...

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Veröffentlicht in:	Organic process research & development 2011-03, Vol.15 (2), p.382-388
Hauptverfasser:	Liu, Jing, Fitzgerald, Anne E, Lebsack, Alec D, Mani, Neelakandha S
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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