Development of Scalable Syntheses of Selective PI3K inhibitors

On the basis of a more practical and scalable route to an iodothiophene, an efficient and reliable synthesis has been developed for three selective PI3K inhibitors. From this advanced intermediate, the three title compounds were each prepared in five additional steps. Key learnings also include: hig...

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Veröffentlicht in:	Organic process research & development 2011-05, Vol.15 (3), p.556-564
Hauptverfasser:	Huang, Qinhua, Richardson, Paul F, Sach, Neal W, Zhu, Jinjiang, Liu, Kevin K.-C, Smith, Graham L, Bowles, Daniel M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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