Rapid Identification of a Scalable Catalyst for the Asymmetric Hydrogenation of a Sterically Demanding Aryl Enamide

High throughput screening was used to find a cost-effective and scalable catalyst for the asymmetric hydrogenation of a sterically demanding enamide as an intermediate towards a new potent melanocortin receptor agonist useful in the treatment of obesity. Lessons drawn from the testing of a first lib...

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Veröffentlicht in:	Organic process research & development 2010-05, Vol.14 (3), p.568-573
Hauptverfasser:	Lefort, Laurent, Boogers, Jeroen A. F, Kuilman, Thijs, Vijn, Robert Jan, Janssen, John, Straatman, Harrie, de Vries, Johannes G, de Vries, André H. M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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