Synthesis of (S)-3-(N-Methylamino)-1-(2-thienyl)propan-1-ol:  Revisiting Eli Lilly's Resolution−Racemization−Recycle Synthesis of Duloxetine for Its Robust Processes

(±)-3-(N,N-Dimethylamino)-1-(2-thienyl)propan-1-ol (6), prepared from 2-acetylthiophene (4) in a two-step overall yield of 79%, is resolved into (S)-6 of 93% ee as its diastereomeric salt (8) with (S)-mandelic acid (7) according to Eli Lilly's procedures developed for the resolution−racemizatio...

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Veröffentlicht in:	Organic process research & development 2006-09, Vol.10 (5), p.905-913
Hauptverfasser:	Fujima, Yoshito, Ikunaka, Masaya, Inoue, Toru, Matsumoto, Jun
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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