Efficient Syntheses of AZD4407 via Thioether Formation by Nucleophilic Attack of Organometallic Species on Sulphur

The development of two efficient strategies for the synthesis of AZD4407 is reported, both of which are considered suitable for large-scale manufacture. In the first approach, 3-bromothiophene is coupled with (2S)-2-methyltetrahydropyran-4-one using Grignard chemistry. Following hydroxyl protection...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Organic process research & development 2005-09, Vol.9 (5), p.555-569
Hauptverfasser:	Alcaraz, Marie-Lyne, Atkinson, Stéphanie, Cornwall, Philip, Foster, Alison C, Gill, Duncan M, Humphries, Lesley A, Keegan, Philip S, Kemp, Richard, Merifield, Eric, Nixon, Robert A, Noble, Allison J, O'Beirne, Darren, Patel, Zakariya M, Perkins, Jacob, Rowan, Paul, Sadler, Paul, Singleton, John T, Tornos, James, Watts, Andrew J, Woodland, Ian A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!