Development of a Manufacturing Process for Sibenadet Hydrochloride, the Active Ingredient of Viozan

A process for commercial manufacture of the dual D2-β2 receptor agonist sibenadet hydrochloride has been developed. The process relies upon introduction of operationally simple chemistry at the final stages where two key intermediates are reacted to assemble the final molecule, isolated by crystalli...

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Veröffentlicht in:	Organic process research & development 2004-07, Vol.8 (4), p.628-642
Hauptverfasser:	Giles, Melvyn E., Thomson, Colin, Eyley, Stephen C., Cole, Andrea J., Goodwin, Christopher J., Hurved, Paul A., Morlin, Andrew J. G., Tornos, James, Atkinson, Stéphanie, Just, Cecelia, Dean, Janet C., Singleton, John T., Longton, Andrew J., Woodland, Ian, Teasdale, Andrew, Gregertsen, Björn, Else, Howard, Athwal, Mandip S., Tatterton, Stephen, Knott, Jason M., Thompson, Nicola, Smith, Stephen J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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