A “Bottom-Up” Approach to Process Development:  Application of Physicochemical Properties of Reaction Products toward the Development of Direct-Drop Processes

A “Bottom-Up” Approach to Process Development:  Application of Physicochemical Properties of Reaction Products toward the Development of Direct-Drop Processes

The “bottom-up” approach to development of direct-drop processes is a powerful, yet simple, strategy that every process chemist should consider for the development of efficient, cost-effective, and environmentally friendly processes. This approach is aided by a “parallel crystallization” technique,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic process research & development 2001-09, Vol.5 (5), p.508-513
Hauptverfasser: Chen, Chien-Kuang, Singh, Ambarish K
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 513
container_issue 5
container_start_page 508
container_title Organic process research & development
container_volume 5
creator Chen, Chien-Kuang
Singh, Ambarish K
description The “bottom-up” approach to development of direct-drop processes is a powerful, yet simple, strategy that every process chemist should consider for the development of efficient, cost-effective, and environmentally friendly processes. This approach is aided by a “parallel crystallization” technique, which allows for rapid identification of multiple solvent systems for the crystallization of the desired product using a minimal amount of material and solvent. This “bottom-up” approach is illustrated by several examples where the desired product is crystallized directly from the reaction mixture.
doi_str_mv 10.1021/op0102114
format Article
fullrecord <record><control><sourceid>acs_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1021_op0102114</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>a269310271</sourcerecordid><originalsourceid>FETCH-LOGICAL-a257t-a5f00e58f78f594f7e13c705d11d5badaf3299448347f5ac953f6156bba13413</originalsourceid><addsrcrecordid>eNptkL9OwzAQxi0EEqUw8AZeGBgCdhLnD1tp-SdVokJFYotc56ykSmrLdkHduvIOsPFkfRIcCoiB6U7f_e6704fQMSVnlIT0XGnSVRrvoB5lIQlYljzt-p5kUZDQhOyjA2vnhBCW0LCHPgZ4s367VM6pNnjUm_U7HmhtFBcVdgpPjBJgLR7BMzRKt7BwF5v1a8c0teCuVgusJJ5UK1sLJSpovdp0axqMq8F20wfg4ov0crkUznrnF25K7Cr469yxo9qAcMHIG_wcB3uI9iRvLBx91z6aXl9Nh7fB-P7mbjgYBzxkqQs4k4QAy2SaSZbHMgUaiZSwktKSzXjJZRTmeRxnUZxKxkXOIplQlsxmnEYxjfrodGsrjLLWgCy0qVtuVgUlRZdq8ZuuZ0-2LBe2mKulWfjH_uE-ARf6fkc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>A “Bottom-Up” Approach to Process Development:  Application of Physicochemical Properties of Reaction Products toward the Development of Direct-Drop Processes</title><source>American Chemical Society Journals</source><creator>Chen, Chien-Kuang ; Singh, Ambarish K</creator><creatorcontrib>Chen, Chien-Kuang ; Singh, Ambarish K</creatorcontrib><description>The “bottom-up” approach to development of direct-drop processes is a powerful, yet simple, strategy that every process chemist should consider for the development of efficient, cost-effective, and environmentally friendly processes. This approach is aided by a “parallel crystallization” technique, which allows for rapid identification of multiple solvent systems for the crystallization of the desired product using a minimal amount of material and solvent. This “bottom-up” approach is illustrated by several examples where the desired product is crystallized directly from the reaction mixture.</description><identifier>ISSN: 1083-6160</identifier><identifier>EISSN: 1520-586X</identifier><identifier>DOI: 10.1021/op0102114</identifier><language>eng</language><publisher>American Chemical Society</publisher><ispartof>Organic process research &amp; development, 2001-09, Vol.5 (5), p.508-513</ispartof><rights>Copyright © 2001 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a257t-a5f00e58f78f594f7e13c705d11d5badaf3299448347f5ac953f6156bba13413</citedby><cites>FETCH-LOGICAL-a257t-a5f00e58f78f594f7e13c705d11d5badaf3299448347f5ac953f6156bba13413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/op0102114$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/op0102114$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids></links><search><creatorcontrib>Chen, Chien-Kuang</creatorcontrib><creatorcontrib>Singh, Ambarish K</creatorcontrib><title>A “Bottom-Up” Approach to Process Development:  Application of Physicochemical Properties of Reaction Products toward the Development of Direct-Drop Processes</title><title>Organic process research &amp; development</title><addtitle>Org. Process Res. Dev</addtitle><description>The “bottom-up” approach to development of direct-drop processes is a powerful, yet simple, strategy that every process chemist should consider for the development of efficient, cost-effective, and environmentally friendly processes. This approach is aided by a “parallel crystallization” technique, which allows for rapid identification of multiple solvent systems for the crystallization of the desired product using a minimal amount of material and solvent. This “bottom-up” approach is illustrated by several examples where the desired product is crystallized directly from the reaction mixture.</description><issn>1083-6160</issn><issn>1520-586X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNptkL9OwzAQxi0EEqUw8AZeGBgCdhLnD1tp-SdVokJFYotc56ykSmrLdkHduvIOsPFkfRIcCoiB6U7f_e6704fQMSVnlIT0XGnSVRrvoB5lIQlYljzt-p5kUZDQhOyjA2vnhBCW0LCHPgZ4s367VM6pNnjUm_U7HmhtFBcVdgpPjBJgLR7BMzRKt7BwF5v1a8c0teCuVgusJJ5UK1sLJSpovdp0axqMq8F20wfg4ov0crkUznrnF25K7Cr469yxo9qAcMHIG_wcB3uI9iRvLBx91z6aXl9Nh7fB-P7mbjgYBzxkqQs4k4QAy2SaSZbHMgUaiZSwktKSzXjJZRTmeRxnUZxKxkXOIplQlsxmnEYxjfrodGsrjLLWgCy0qVtuVgUlRZdq8ZuuZ0-2LBe2mKulWfjH_uE-ARf6fkc</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>Chen, Chien-Kuang</creator><creator>Singh, Ambarish K</creator><general>American Chemical Society</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20010901</creationdate><title>A “Bottom-Up” Approach to Process Development:  Application of Physicochemical Properties of Reaction Products toward the Development of Direct-Drop Processes</title><author>Chen, Chien-Kuang ; Singh, Ambarish K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a257t-a5f00e58f78f594f7e13c705d11d5badaf3299448347f5ac953f6156bba13413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Chien-Kuang</creatorcontrib><creatorcontrib>Singh, Ambarish K</creatorcontrib><collection>CrossRef</collection><jtitle>Organic process research &amp; development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Chien-Kuang</au><au>Singh, Ambarish K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A “Bottom-Up” Approach to Process Development:  Application of Physicochemical Properties of Reaction Products toward the Development of Direct-Drop Processes</atitle><jtitle>Organic process research &amp; development</jtitle><addtitle>Org. Process Res. Dev</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>5</volume><issue>5</issue><spage>508</spage><epage>513</epage><pages>508-513</pages><issn>1083-6160</issn><eissn>1520-586X</eissn><abstract>The “bottom-up” approach to development of direct-drop processes is a powerful, yet simple, strategy that every process chemist should consider for the development of efficient, cost-effective, and environmentally friendly processes. This approach is aided by a “parallel crystallization” technique, which allows for rapid identification of multiple solvent systems for the crystallization of the desired product using a minimal amount of material and solvent. This “bottom-up” approach is illustrated by several examples where the desired product is crystallized directly from the reaction mixture.</abstract><pub>American Chemical Society</pub><doi>10.1021/op0102114</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1083-6160
ispartof Organic process research & development, 2001-09, Vol.5 (5), p.508-513
issn 1083-6160
1520-586X
language eng
recordid cdi_crossref_primary_10_1021_op0102114
source American Chemical Society Journals
title A “Bottom-Up” Approach to Process Development:  Application of Physicochemical Properties of Reaction Products toward the Development of Direct-Drop Processes
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T13%3A28%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-acs_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20%E2%80%9CBottom-Up%E2%80%9D%20Approach%20to%20Process%20Development:%E2%80%89%20Application%20of%20Physicochemical%20Properties%20of%20Reaction%20Products%20toward%20the%20Development%20of%20Direct-Drop%20Processes&rft.jtitle=Organic%20process%20research%20&%20development&rft.au=Chen,%20Chien-Kuang&rft.date=2001-09-01&rft.volume=5&rft.issue=5&rft.spage=508&rft.epage=513&rft.pages=508-513&rft.issn=1083-6160&rft.eissn=1520-586X&rft_id=info:doi/10.1021/op0102114&rft_dat=%3Cacs_cross%3Ea269310271%3C/acs_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true