The Synthesis of 17α-Methyl-11β-arylestradiol:  Large-Scale Application of the Cerium (III)-Mediated Alkylation of a Ketone

17α-Methyl-11β-arylestradiol (17α-methyl-11β-(4-(2-(1-piperidinyl)ethoxy)phenyl)estra-1,3,5(10)-triene-3,17β-diol) is a new molecule developed by Aventis Pharma for the treatment of osteoporosis. It was produced on the pilot plant scale from the norsteroid intermediate ethylene deltenone (3,3-ethyle...

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Veröffentlicht in:	Organic process research & development 2002-01, Vol.6 (1), p.20-27
Hauptverfasser:	Larkin, John Patrick, Wehrey, Christian, Boffelli, Philippe, Lagraulet, Henri, Lemaitre, Guy, Nedelec, Alban, Prat, Denis
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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