Synthesis of S,S,O‑Orthoesters and 1,1-Difluoroalkyl Ethers via Reaction of Peroxides with Lithiated 1,3-Dithianes

Alkyl tetrahydropyranyl peroxides (ROOTHP) transfer alkoxide (OR) to lithiated 1,3-dithianes. The derived S,S,O-orthoesters undergo fluorodesulfurization with HF/pyridine and N-bromosuccinamide (NBS) to furnish difluoromethyl ethers. The overall protocol can be applied to synthesis of both terminal...

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Veröffentlicht in:	Organic letters 2014-10, Vol.16 (20), p.5235-5237
Hauptverfasser:	Kyasa, Shiva K., Dussault, Patrick H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ethers - chemical synthesis Ethers - chemistry Heterocyclic Compounds - chemistry Molecular Structure Peroxides - chemistry Pyridines - chemistry
Online-Zugang:	Volltext
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