Rapid Assembly and in Situ Screening of Bidentate Inhibitors of Protein Tyrosine Phosphatases

We have successfully designed and synthesized a small library of protein tyrosine phosphatase (PTP) inhibitors, in which the so-called “click chemistry” or Cu(I)-catalyzed 1,3-dipolar alkyne−azide coupling reaction was carried out for rapid assembly of 66 different bidentate compounds. Subsequent in...

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Veröffentlicht in:	Organic letters 2006-02, Vol.8 (4), p.713-716
Hauptverfasser:	Srinivasan, Rajavel, Uttamchandani, Mahesh, Yao, Shao Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - drug effects Combinatorial Chemistry Techniques Inhibitory Concentration 50 Isoxazoles - chemical synthesis Isoxazoles - chemistry Isoxazoles - pharmacology Molecular Structure Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases - antagonists & inhibitors Triazoles - chemical synthesis Triazoles - chemistry Triazoles - pharmacology
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