Reductive and Catalytic Monoalkylation of Primary Amines Using Nitriles as an Alkylating Reagent

Reductive and Catalytic Monoalkylation of Primary Amines Using Nitriles as an Alkylating Reagent

A selective and catalytic mono-N-alkylation method of both aromatic and aliphatic amines using nitriles as an alkylating agent with Pd/C or Rh/C as a catalyst is described. This method is particularly attractive to provide an environmentally benign and applicable alkylation method of amines without...

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Veröffentlicht in:Organic letters 2004-12, Vol.6 (26), p.4977-4980
Hauptverfasser: Sajiki, Hironao, Ikawa, Takashi, Hirota, Kosaku
Format: Artikel
Sprache:eng
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Alkylation
Amines - chemical synthesis
Amines - chemistry
Catalysis
Molecular Structure
Nitriles - chemistry
Oxidation-Reduction
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container_title Organic letters
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creator Sajiki, Hironao
Ikawa, Takashi
Hirota, Kosaku
description A selective and catalytic mono-N-alkylation method of both aromatic and aliphatic amines using nitriles as an alkylating agent with Pd/C or Rh/C as a catalyst is described. This method is particularly attractive to provide an environmentally benign and applicable alkylation method of amines without using toxic and corrosive alkylating agents such as alkyl halides and carbonyl compounds.
doi_str_mv 10.1021/ol047871o
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source MEDLINE; ACS Publications
subjects Alkylation
Amines - chemical synthesis
Amines - chemistry
Catalysis
Molecular Structure
Nitriles - chemistry
Oxidation-Reduction
title Reductive and Catalytic Monoalkylation of Primary Amines Using Nitriles as an Alkylating Reagent
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