s eco-C/D Ring Analogues of Ergot Alkaloids. Synthesis via Intramolecular Heck and Ring-Closing Metathesis Reactions

s eco-C/D Ring Analogues of Ergot Alkaloids. Synthesis via Intramolecular Heck and Ring-Closing Metathesis Reactions

Intramolecular Heck and ring-closing metathesis reactions on key intermediates 10 and 15, respectively, provide efficient entries into seco-C/D ring analogues of Ergot alkaloids 12 and 16, compounds of potential synthetic and biological interest.

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Veröffentlicht in:Organic letters 2003-09, Vol.5 (19), p.3519-3521
Hauptverfasser: Kalinin, Alexey V, Chauder, Brian A, Rakhit, Suman, Snieckus, Victor
Format: Artikel
Sprache:eng
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Zusammenfassung:Intramolecular Heck and ring-closing metathesis reactions on key intermediates 10 and 15, respectively, provide efficient entries into seco-C/D ring analogues of Ergot alkaloids 12 and 16, compounds of potential synthetic and biological interest.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol035398t