Cobalt-Catalyzed Cycloisomerization of 1,6-Enynes and Allyl Propargyl Ethers
1,6-Enynes and allyl propargyl ethers undergo a cobalt-catalyzed formal 5-endo-dig cyclization to form vinyl cyclopentenes and dihydrofurans, respectively. The use of equimolar amounts of dicobalt octacarbonyl and trimethyl phosphite affords optimum yields and improved selectivity for cycloisomeriza...
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| Veröffentlicht in: | Organic letters 2003-07, Vol.5 (14), p.2409-2411 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | 1,6-Enynes and allyl propargyl ethers undergo a cobalt-catalyzed formal 5-endo-dig cyclization to form vinyl cyclopentenes and dihydrofurans, respectively. The use of equimolar amounts of dicobalt octacarbonyl and trimethyl phosphite affords optimum yields and improved selectivity for cycloisomerization vs alkene isomerization. |
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| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.1021/ol034541f |