Tentoxin as a Scaffold for Drug Discovery. Total Solid-Phase Synthesis of Tentoxin and a Library of Analogues

A solid-phase method for the synthesis of tentoxin has been developed. Two key stepsdehydration and N-alkylationare carried out while the peptide is anchored to the resin. The method, which has been validated by the preparation of a library of tentoxin analogues, should be applicable to the genera...

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Veröffentlicht in:	Organic letters 2003-06, Vol.5 (12), p.2115-2118
Hauptverfasser:	Jiménez, Jose C, Chavarría, Bibiana, López-Macià, Àngel, Royo, Miriam, Giralt, Ernest, Albericio, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Combinatorial Chemistry Techniques Mycotoxins - analogs & derivatives Mycotoxins - chemical synthesis Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Structure-Activity Relationship
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