Tentoxin as a Scaffold for Drug Discovery. Total Solid-Phase Synthesis of Tentoxin and a Library of Analogues
A solid-phase method for the synthesis of tentoxin has been developed. Two key stepsdehydration and N-alkylationare carried out while the peptide is anchored to the resin. The method, which has been validated by the preparation of a library of tentoxin analogues, should be applicable to the genera...
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| Veröffentlicht in: | Organic letters 2003-06, Vol.5 (12), p.2115-2118 |
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| container_end_page | 2118 |
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| container_issue | 12 |
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| container_title | Organic letters |
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| creator | Jiménez, Jose C Chavarría, Bibiana López-Macià, Àngel Royo, Miriam Giralt, Ernest Albericio, Fernando |
| description | A solid-phase method for the synthesis of tentoxin has been developed. Two key stepsdehydration and N-alkylationare carried out while the peptide is anchored to the resin. The method, which has been validated by the preparation of a library of tentoxin analogues, should be applicable to the generation of further libraries that have the tentoxin scaffold structure, as well as other structures containing N-alkylated didehydroamino acids. |
| doi_str_mv | 10.1021/ol0345273 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2003-06, Vol.5 (12), p.2115-2118 |
| issn | 1523-7060 1523-7052 |
| language | eng |
| recordid | cdi_crossref_primary_10_1021_ol0345273 |
| source | MEDLINE; ACS Publications |
| subjects | Amino Acid Sequence Combinatorial Chemistry Techniques Mycotoxins - analogs & derivatives Mycotoxins - chemical synthesis Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Structure-Activity Relationship |
| title | Tentoxin as a Scaffold for Drug Discovery. Total Solid-Phase Synthesis of Tentoxin and a Library of Analogues |
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