Anti-HIV-1 Protease Activity of Lanostane Triterpenes from the Vietnamese Mushroom Ganoderma colossum
Four new lanostane triterpenes, colossolactone V (1), colossolactone VI (2), colossolactone VII (3), and colossolactone VIII (4), were isolated from the fruiting bodies of the Vietnamese mushroom Ganoderma colossum, together with the known compound colossolactone E (5). The structures of 1−4 were as...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2008-06, Vol.71 (6), p.1022-1026 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | El Dine, Riham Salah El Halawany, Ali M Ma, Chao-Mei Hattori, Masao |
| description | Four new lanostane triterpenes, colossolactone V (1), colossolactone VI (2), colossolactone VII (3), and colossolactone VIII (4), were isolated from the fruiting bodies of the Vietnamese mushroom Ganoderma colossum, together with the known compound colossolactone E (5). The structures of 1−4 were assigned on the basis of spectroscopic evidence, and their absolute configurations were determined by CD spectroscopy and the Mosher ester method. Compounds 1−5, as well as two previously isolated compounds [schisanlactone A (6) and colossolactone G (7)] from the same mushroom, were evaluated for inhibition of HIV-1 protease, with IC50 values for the most potent compounds ranging from 5 to 13 µg/mL. |
| doi_str_mv | 10.1021/np8001139 |
| format | Article |
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The structures of 1−4 were assigned on the basis of spectroscopic evidence, and their absolute configurations were determined by CD spectroscopy and the Mosher ester method. Compounds 1−5, as well as two previously isolated compounds [schisanlactone A (6) and colossolactone G (7)] from the same mushroom, were evaluated for inhibition of HIV-1 protease, with IC50 values for the most potent compounds ranging from 5 to 13 µg/mL.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np8001139</identifier><identifier>PMID: 18547117</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society and American Society of Pharmacognosy</publisher><subject>Biological and medical sciences ; Ganoderma - chemistry ; General pharmacology ; HIV Protease - drug effects ; HIV Protease Inhibitors - chemistry ; HIV Protease Inhibitors - isolation & purification ; HIV Protease Inhibitors - pharmacology ; HIV-1 - drug effects ; Humans ; Inhibitory Concentration 50 ; Lanosterol - analogs & derivatives ; Lanosterol - chemistry ; Lanosterol - isolation & purification ; Medical sciences ; Molecular Structure ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Triterpenes - chemistry ; Triterpenes - isolation & purification ; Triterpenes - pharmacology ; Vietnam</subject><ispartof>Journal of natural products (Washington, D.C.), 2008-06, Vol.71 (6), p.1022-1026</ispartof><rights>Copyright © 2008 American Chemical Society and American Society of Pharmacognosy</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a447t-10ecd8512f6064878c38b4ea1699fbd16f52a0e96c754c4fce33525dcad9c61c3</citedby><cites>FETCH-LOGICAL-a447t-10ecd8512f6064878c38b4ea1699fbd16f52a0e96c754c4fce33525dcad9c61c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np8001139$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np8001139$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56717,56767</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20480253$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18547117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El Dine, Riham Salah</creatorcontrib><creatorcontrib>El Halawany, Ali M</creatorcontrib><creatorcontrib>Ma, Chao-Mei</creatorcontrib><creatorcontrib>Hattori, Masao</creatorcontrib><title>Anti-HIV-1 Protease Activity of Lanostane Triterpenes from the Vietnamese Mushroom Ganoderma colossum</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Four new lanostane triterpenes, colossolactone V (1), colossolactone VI (2), colossolactone VII (3), and colossolactone VIII (4), were isolated from the fruiting bodies of the Vietnamese mushroom Ganoderma colossum, together with the known compound colossolactone E (5). The structures of 1−4 were assigned on the basis of spectroscopic evidence, and their absolute configurations were determined by CD spectroscopy and the Mosher ester method. Compounds 1−5, as well as two previously isolated compounds [schisanlactone A (6) and colossolactone G (7)] from the same mushroom, were evaluated for inhibition of HIV-1 protease, with IC50 values for the most potent compounds ranging from 5 to 13 µg/mL.</description><subject>Biological and medical sciences</subject><subject>Ganoderma - chemistry</subject><subject>General pharmacology</subject><subject>HIV Protease - drug effects</subject><subject>HIV Protease Inhibitors - chemistry</subject><subject>HIV Protease Inhibitors - isolation & purification</subject><subject>HIV Protease Inhibitors - pharmacology</subject><subject>HIV-1 - drug effects</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Lanosterol - analogs & derivatives</subject><subject>Lanosterol - chemistry</subject><subject>Lanosterol - isolation & purification</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Triterpenes - chemistry</subject><subject>Triterpenes - isolation & purification</subject><subject>Triterpenes - pharmacology</subject><subject>Vietnam</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkD1PwzAQhi0EgvIx8AeQFwaGgC_-SDJWCEpFEZUoDCyW65xFoEkq20Xw7zFqVRamk-6e9-70EHIK7BJYDlfdsmQMgFc7ZAAyZ5liudwlAwaKZ7xU4oAchvDOGOOskvvkAEopCoBiQHDYxSa7G79kQKe-j2gC0qGNzWcTv2nv6MR0fYimQzrzTUS_xA4Ddb5vaXxD-tJg7EyLKfWwCm--T_1RitToW0Ntv-hDWLXHZM-ZRcCTTT0iz7c3s-u7bPI4Gl8PJ5kRoogZMLR1KSF3iilRFqXl5VygAVVVbl6DcjI3DCtlCymscBY5l7msrakrq8DyI3Kx3mt9uuvR6aVvWuO_NTD9q0pvVSX2bM0uV_MW6z9y4yYB5xvABGsWzpvONmHL5UyUSTNPXLbmmhDxazs3_kOrghdSz6ZP-vVJjR7uBdfV315jg37vV75LSv558AcEPYwO</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>El Dine, Riham Salah</creator><creator>El Halawany, Ali M</creator><creator>Ma, Chao-Mei</creator><creator>Hattori, Masao</creator><general>American Chemical Society and American Society of Pharmacognosy</general><general>American Society of Pharmacognosy</general><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20080601</creationdate><title>Anti-HIV-1 Protease Activity of Lanostane Triterpenes from the Vietnamese Mushroom Ganoderma colossum</title><author>El Dine, Riham Salah ; El Halawany, Ali M ; Ma, Chao-Mei ; Hattori, Masao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a447t-10ecd8512f6064878c38b4ea1699fbd16f52a0e96c754c4fce33525dcad9c61c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Ganoderma - chemistry</topic><topic>General pharmacology</topic><topic>HIV Protease - drug effects</topic><topic>HIV Protease Inhibitors - chemistry</topic><topic>HIV Protease Inhibitors - isolation & purification</topic><topic>HIV Protease Inhibitors - pharmacology</topic><topic>HIV-1 - drug effects</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Lanosterol - analogs & derivatives</topic><topic>Lanosterol - chemistry</topic><topic>Lanosterol - isolation & purification</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Triterpenes - chemistry</topic><topic>Triterpenes - isolation & purification</topic><topic>Triterpenes - pharmacology</topic><topic>Vietnam</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Dine, Riham Salah</creatorcontrib><creatorcontrib>El Halawany, Ali M</creatorcontrib><creatorcontrib>Ma, Chao-Mei</creatorcontrib><creatorcontrib>Hattori, Masao</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Dine, Riham Salah</au><au>El Halawany, Ali M</au><au>Ma, Chao-Mei</au><au>Hattori, Masao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-HIV-1 Protease Activity of Lanostane Triterpenes from the Vietnamese Mushroom Ganoderma colossum</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>71</volume><issue>6</issue><spage>1022</spage><epage>1026</epage><pages>1022-1026</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Four new lanostane triterpenes, colossolactone V (1), colossolactone VI (2), colossolactone VII (3), and colossolactone VIII (4), were isolated from the fruiting bodies of the Vietnamese mushroom Ganoderma colossum, together with the known compound colossolactone E (5). The structures of 1−4 were assigned on the basis of spectroscopic evidence, and their absolute configurations were determined by CD spectroscopy and the Mosher ester method. Compounds 1−5, as well as two previously isolated compounds [schisanlactone A (6) and colossolactone G (7)] from the same mushroom, were evaluated for inhibition of HIV-1 protease, with IC50 values for the most potent compounds ranging from 5 to 13 µg/mL.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society and American Society of Pharmacognosy</pub><pmid>18547117</pmid><doi>10.1021/np8001139</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2008-06, Vol.71 (6), p.1022-1026 |
| issn | 0163-3864 1520-6025 |
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| source | MEDLINE; American Chemical Society Publications |
| subjects | Biological and medical sciences Ganoderma - chemistry General pharmacology HIV Protease - drug effects HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - isolation & purification HIV Protease Inhibitors - pharmacology HIV-1 - drug effects Humans Inhibitory Concentration 50 Lanosterol - analogs & derivatives Lanosterol - chemistry Lanosterol - isolation & purification Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology Vietnam |
| title | Anti-HIV-1 Protease Activity of Lanostane Triterpenes from the Vietnamese Mushroom Ganoderma colossum |
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