Identification of 3-Hydroxy-3-methylglutaric Acid (HMG) as a Hypoglycemic Principle of Spanish Moss (Tillandsia usneoides)

Bioactivity-directed fractionation, using brine shrimp lethality and murine hypoglycemia, of an ethanol extract prepared from Tillandsia usneoides, led to the isolation of four apparently bioactive compounds from the water-soluble fraction. The compounds were identified as citric acid, succinic acid...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1995-08, Vol.58 (8), p.1285-1290
Hauptverfasser:	Witherup, K. M, McLaughlin, J. L, Judd, R. L, Ziegler, M. H, Medon, P. J, Keller, W. J
Format:	Artikel
Sprache:	eng
Schlagworte:	ACIDE ORGANIQUE ACIDOS ORGANICOS Animals Artemia BIOASSAYS Blood Glucose - metabolism CHEMICAL COMPOSITION Chromatography, Thin Layer COMPOSICION QUIMICA COMPOSITION CHIMIQUE DERIVATIVES DOSAGE BIOLOGIQUE DRUG PLANTS DRUGS ENSAYO BIOLOGICO HIPOGLICEMIA HYPOGLYCAEMIA Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Hypoglycemic Agents - toxicity HYPOGLYCEMIE Lethal Dose 50 LOUISIANA LOUISIANE LUISIANA Magnetic Resonance Spectroscopy Male Mass Spectrometry MEDICAMENT MEDICAMENTOS Meglutol - chemistry Meglutol - pharmacology Meglutol - toxicity Mice ORGANIC ACIDS PLANTAS MEDICINALES PLANTE MEDICINALE Plants, Medicinal - chemistry Spectrophotometry, Infrared TILLANDSIA
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