Synergistic Effect of Flavones and Flavonols Against Herpes Simplex Virus Type 1 in Cell Culture. Comparison with the Antiviral Activity of Propolis
The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol co...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 1992-12, Vol.55 (12), p.1732-1740 |
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| container_issue | 12 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Amoros, M Simõs, C. M. O Girre, L Sauvager, F Cormier, M |
| description | The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol combinations has been also investigated. The synergy demonstrated by all combinations could explain why propolis is more active than its individual compounds. |
| doi_str_mv | 10.1021/np50090a003 |
| format | Article |
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Comparison with the Antiviral Activity of Propolis</title><source>MEDLINE</source><source>ACS Publications</source><creator>Amoros, M ; Simõs, C. M. O ; Girre, L ; Sauvager, F ; Cormier, M</creator><creatorcontrib>Amoros, M ; Simõs, C. M. O ; Girre, L ; Sauvager, F ; Cormier, M</creatorcontrib><description>The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol combinations has been also investigated. The synergy demonstrated by all combinations could explain why propolis is more active than its individual compounds.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np50090a003</identifier><identifier>PMID: 1338212</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; ANTIVIRAL ; ANTIVIRAL AGENTS ; Antiviral Agents - pharmacology ; ARBOLES ; ARBRE ; Biological and medical sciences ; CELL CULTURE ; Cell Survival - drug effects ; CULTIVO DE CELULAS ; CULTURE DE CELLULE ; CYTOTOXICITY ; Drug Synergism ; DRUGS ; EXTRACTOS VEGETALES ; EXTRAIT D'ORIGINE VEGETALE ; FLAVONOIDE ; FLAVONOIDES ; FLAVONOIDS ; Flavonoids - pharmacology ; Flavonols ; General pharmacology ; HERPETOVIRIDAE ; Medical sciences ; MEDICAMENT ; MEDICAMENTOS ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; PLANT EXTRACTS ; PROPOLEOS ; PROPOLIS ; Propolis - chemistry ; Propolis - pharmacology ; Simplexvirus - drug effects ; SINERGISMO ; SYNERGIE ; SYNERGISM ; TOXICIDAD ; TOXICITE ; TOXICITY ; TREES ; Vero Cells ; Viral Plaque Assay ; VIRICIDAS ; Virus Replication - drug effects</subject><ispartof>Journal of natural products (Washington, D.C.), 1992-12, Vol.55 (12), p.1732-1740</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a402t-17778dea07898ec7cc7662915070871c63d9aad408d87e0084a520c33a9ab8d63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np50090a003$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np50090a003$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56716,56766</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4461869$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1338212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amoros, M</creatorcontrib><creatorcontrib>Simõs, C. M. O</creatorcontrib><creatorcontrib>Girre, L</creatorcontrib><creatorcontrib>Sauvager, F</creatorcontrib><creatorcontrib>Cormier, M</creatorcontrib><title>Synergistic Effect of Flavones and Flavonols Against Herpes Simplex Virus Type 1 in Cell Culture. Comparison with the Antiviral Activity of Propolis</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol combinations has been also investigated. The synergy demonstrated by all combinations could explain why propolis is more active than its individual compounds.</description><subject>Animals</subject><subject>ANTIVIRAL</subject><subject>ANTIVIRAL AGENTS</subject><subject>Antiviral Agents - pharmacology</subject><subject>ARBOLES</subject><subject>ARBRE</subject><subject>Biological and medical sciences</subject><subject>CELL CULTURE</subject><subject>Cell Survival - drug effects</subject><subject>CULTIVO DE CELULAS</subject><subject>CULTURE DE CELLULE</subject><subject>CYTOTOXICITY</subject><subject>Drug Synergism</subject><subject>DRUGS</subject><subject>EXTRACTOS VEGETALES</subject><subject>EXTRAIT D'ORIGINE VEGETALE</subject><subject>FLAVONOIDE</subject><subject>FLAVONOIDES</subject><subject>FLAVONOIDS</subject><subject>Flavonoids - pharmacology</subject><subject>Flavonols</subject><subject>General pharmacology</subject><subject>HERPETOVIRIDAE</subject><subject>Medical sciences</subject><subject>MEDICAMENT</subject><subject>MEDICAMENTOS</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>PLANT EXTRACTS</subject><subject>PROPOLEOS</subject><subject>PROPOLIS</subject><subject>Propolis - chemistry</subject><subject>Propolis - pharmacology</subject><subject>Simplexvirus - drug effects</subject><subject>SINERGISMO</subject><subject>SYNERGIE</subject><subject>SYNERGISM</subject><subject>TOXICIDAD</subject><subject>TOXICITE</subject><subject>TOXICITY</subject><subject>TREES</subject><subject>Vero Cells</subject><subject>Viral Plaque Assay</subject><subject>VIRICIDAS</subject><subject>Virus Replication - drug effects</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEFv0zAYQC0EGt3gxA0JyQckDijDjhPbOVZho4hKTGrHgYv1zXE6D9eO7GSs_2M_mESpBgdO_qz3ZH96CL2h5JySnH7yXUlIRYAQ9gwtaJmTjJO8fI4WhHKWMcmLl-g0pTsyGqQqT9AJZUzmNF-gx83Bm7izqbcaX7St0T0OLb50cB-8SRh8c7wEl_ByB9anHq9M7Ea4sfvOmQf8w8Yh4e2hM5hi63FtnMP14PohmnNch30H0abg8W_b3-L-1uCl7-29jeDwUk9Tf5h-vYqhC86mV-hFCy6Z18fzDF1fXmzrVbb-_uVrvVxnUJC8z6gQQjYGiJCVNFpoLTjPK1oSQaSgmrOmAmgKIhspDCGygLGNZgwquJENZ2fo4_yujiGlaFrVRbuHeFCUqCmt-iftaL-b7W642Zvmrzu3HPn7I4ekwbURvLbpSSsKTiWvRi2btbG5eXjCEH8pLpgo1fZqo9b5N_Fz9XmtJv_t7LcQFOzGkOp6U7FcMjbt9GGGoJO6C0P0Y6__bv8HnVClKw</recordid><startdate>19921201</startdate><enddate>19921201</enddate><creator>Amoros, M</creator><creator>Simõs, C. M. O</creator><creator>Girre, L</creator><creator>Sauvager, F</creator><creator>Cormier, M</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19921201</creationdate><title>Synergistic Effect of Flavones and Flavonols Against Herpes Simplex Virus Type 1 in Cell Culture. Comparison with the Antiviral Activity of Propolis</title><author>Amoros, M ; Simõs, C. M. O ; Girre, L ; Sauvager, F ; Cormier, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a402t-17778dea07898ec7cc7662915070871c63d9aad408d87e0084a520c33a9ab8d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>ANTIVIRAL</topic><topic>ANTIVIRAL AGENTS</topic><topic>Antiviral Agents - pharmacology</topic><topic>ARBOLES</topic><topic>ARBRE</topic><topic>Biological and medical sciences</topic><topic>CELL CULTURE</topic><topic>Cell Survival - drug effects</topic><topic>CULTIVO DE CELULAS</topic><topic>CULTURE DE CELLULE</topic><topic>CYTOTOXICITY</topic><topic>Drug Synergism</topic><topic>DRUGS</topic><topic>EXTRACTOS VEGETALES</topic><topic>EXTRAIT D'ORIGINE VEGETALE</topic><topic>FLAVONOIDE</topic><topic>FLAVONOIDES</topic><topic>FLAVONOIDS</topic><topic>Flavonoids - pharmacology</topic><topic>Flavonols</topic><topic>General pharmacology</topic><topic>HERPETOVIRIDAE</topic><topic>Medical sciences</topic><topic>MEDICAMENT</topic><topic>MEDICAMENTOS</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>PLANT EXTRACTS</topic><topic>PROPOLEOS</topic><topic>PROPOLIS</topic><topic>Propolis - chemistry</topic><topic>Propolis - pharmacology</topic><topic>Simplexvirus - drug effects</topic><topic>SINERGISMO</topic><topic>SYNERGIE</topic><topic>SYNERGISM</topic><topic>TOXICIDAD</topic><topic>TOXICITE</topic><topic>TOXICITY</topic><topic>TREES</topic><topic>Vero Cells</topic><topic>Viral Plaque Assay</topic><topic>VIRICIDAS</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amoros, M</creatorcontrib><creatorcontrib>Simõs, C. M. O</creatorcontrib><creatorcontrib>Girre, L</creatorcontrib><creatorcontrib>Sauvager, F</creatorcontrib><creatorcontrib>Cormier, M</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amoros, M</au><au>Simõs, C. M. O</au><au>Girre, L</au><au>Sauvager, F</au><au>Cormier, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic Effect of Flavones and Flavonols Against Herpes Simplex Virus Type 1 in Cell Culture. Comparison with the Antiviral Activity of Propolis</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>1992-12-01</date><risdate>1992</risdate><volume>55</volume><issue>12</issue><spage>1732</spage><epage>1740</epage><pages>1732-1740</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol combinations has been also investigated. The synergy demonstrated by all combinations could explain why propolis is more active than its individual compounds.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>1338212</pmid><doi>10.1021/np50090a003</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 1992-12, Vol.55 (12), p.1732-1740 |
| issn | 0163-3864 1520-6025 |
| language | eng |
| recordid | cdi_crossref_primary_10_1021_np50090a003 |
| source | MEDLINE; ACS Publications |
| subjects | Animals ANTIVIRAL ANTIVIRAL AGENTS Antiviral Agents - pharmacology ARBOLES ARBRE Biological and medical sciences CELL CULTURE Cell Survival - drug effects CULTIVO DE CELULAS CULTURE DE CELLULE CYTOTOXICITY Drug Synergism DRUGS EXTRACTOS VEGETALES EXTRAIT D'ORIGINE VEGETALE FLAVONOIDE FLAVONOIDES FLAVONOIDS Flavonoids - pharmacology Flavonols General pharmacology HERPETOVIRIDAE Medical sciences MEDICAMENT MEDICAMENTOS Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments PLANT EXTRACTS PROPOLEOS PROPOLIS Propolis - chemistry Propolis - pharmacology Simplexvirus - drug effects SINERGISMO SYNERGIE SYNERGISM TOXICIDAD TOXICITE TOXICITY TREES Vero Cells Viral Plaque Assay VIRICIDAS Virus Replication - drug effects |
| title | Synergistic Effect of Flavones and Flavonols Against Herpes Simplex Virus Type 1 in Cell Culture. Comparison with the Antiviral Activity of Propolis |
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