Synergistic Effect of Flavones and Flavonols Against Herpes Simplex Virus Type 1 in Cell Culture. Comparison with the Antiviral Activity of Propolis

The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol co...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1992-12, Vol.55 (12), p.1732-1740
Hauptverfasser:	Amoros, M, Simõs, C. M. O, Girre, L, Sauvager, F, Cormier, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ANTIVIRAL ANTIVIRAL AGENTS Antiviral Agents - pharmacology ARBOLES ARBRE Biological and medical sciences CELL CULTURE Cell Survival - drug effects CULTIVO DE CELULAS CULTURE DE CELLULE CYTOTOXICITY Drug Synergism DRUGS EXTRACTOS VEGETALES EXTRAIT D'ORIGINE VEGETALE FLAVONOIDE FLAVONOIDES FLAVONOIDS Flavonoids - pharmacology Flavonols General pharmacology HERPETOVIRIDAE Medical sciences MEDICAMENT MEDICAMENTOS Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments PLANT EXTRACTS PROPOLEOS PROPOLIS Propolis - chemistry Propolis - pharmacology Simplexvirus - drug effects SINERGISMO SYNERGIE SYNERGISM TOXICIDAD TOXICITE TOXICITY TREES Vero Cells Viral Plaque Assay VIRICIDAS Virus Replication - drug effects
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Zusammenfassung:	The in vitro activity against herpes simplex virus type 1 of the major flavonoids identified in propolis was investigated. Flavonols were found to be more active than flavones, the order of importance being galangin, kaempferol, and quercetin. The efficacy against HSV-1 of binary flavone-flavonol combinations has been also investigated. The synergy demonstrated by all combinations could explain why propolis is more active than its individual compounds.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50090a003