Isolation, Structure, and Biological Activity of Phaeofungin, a Cyclic Lipodepsipeptide from a Phaeosphaeria sp. Using the Genome-Wide Candida albicans Fitness Test

Phaeofungin (1), a new cyclic depsipeptide isolated from Phaeosphaeria sp., was discovered by application of reverse genetics technology, using the Candida albicans fitness test (CaFT). Phaeofungin is comprised of seven amino acids and a β,γ-dihydroxy-γ-methylhexadecanoic acid arranged in a 25-membe...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2013-03, Vol.76 (3), p.334-345
Hauptverfasser:	Singh, Sheo B, Ondeyka, John, Harris, Guy, Herath, Kithsiri, Zink, Deborah, Vicente, Francisca, Bills, Gerald, Collado, Javier, Platas, Gonzalo, González del Val, Antonio, Martin, Jesus, Reyes, Fernando, Wang, Hao, Kahn, Jennifer Nielsen, Galuska, Stefan, Giacobbe, Robert, Abruzzo, George, Roemer, Terry, Xu, Deming
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Ascomycota - chemistry Candida albicans - drug effects Candida albicans - genetics Crassulaceae - microbiology Depsipeptides - chemistry Depsipeptides - isolation & purification Depsipeptides - pharmacology Echinocandins - chemistry Genome Lipopeptides - chemistry Lipopeptides - isolation & purification Lipopeptides - pharmacology Microbial Sensitivity Tests Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Leaves - microbiology Plant Stems - microbiology
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