Xanthohumol Induces Apoptosis in Human Malignant Glioblastoma Cells by Increasing Reactive Oxygen Species and Activating MAPK Pathways

The effect of the biologically active prenylated chalcone and potential anticancer agent xanthohumol (1) has been investigated on apoptosis of the T98G human malignant glioblastoma cell line. Compound 1 decreased the viability of T98G cells by induction of apoptosis in a time- and concentration-depe...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2011-12, Vol.74 (12), p.2505-2513
Hauptverfasser:	Festa, Michela, Capasso, Anna, D’Acunto, Cosimo W, Masullo, Milena, Rossi, Adriano G, Pizza, Cosimo, Piacente, Sonia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Antineoplastic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Caspase 3 - drug effects Caspase 3 - metabolism Caspase 9 - drug effects Caspase 9 - metabolism Cyclohexenes - chemistry Cyclohexenes - pharmacology Cytochromes c - metabolism Dose-Response Relationship, Drug Flavonoids - chemistry Flavonoids - pharmacology General pharmacology Glioblastoma - drug therapy Glioblastoma - metabolism Humans Imidazoles - pharmacology Italy Medical sciences Mitogen-Activated Protein Kinases - metabolism Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Poly(ADP-ribose) Polymerases - drug effects Poly(ADP-ribose) Polymerases - metabolism Propiophenones - chemistry Propiophenones - pharmacology Pyridines - pharmacology Reactive Oxygen Species - analysis Reactive Oxygen Species - metabolism Terpenes - chemistry Terpenes - pharmacology
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