Cytotoxic Cycloartane Triterpene Saponins from Actaea asiatica

Three new 9,19-cycloartane triterpene glycosides, asiaticoside A (1), asiaticoside B (2), and 25-O-ethylcimigenol-3-O-β-d-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3-β-O-d-xyloside (5), and 25-anhydrocimigenol-β-O-d-xyloside (6) were isolated from the roots/rhizomes...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2006-10, Vol.69 (10), p.1500-1502
Hauptverfasser:	Gao, Jingchun, Huang, Feng, Zhang, Jinchao, Zhu, Guoyuan, Yang, Mengsu, Xiao, Peigen
Format:	Artikel
Sprache:	eng
Schlagworte:	Actaea Actaea - chemistry Actaea asiatica Animals anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology asiaticoside Biological and medical sciences Cell Line, Tumor chemical structure cultured cells cycloartane triterpene cytotoxicity Drug Screening Assays, Antitumor Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology General pharmacology glycosides Humans Inhibitory Concentration 50 Medical sciences medicinal plants Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oriental traditional medicine Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Roots - chemistry Plants, Medicinal - chemistry Ranunculaceae Rhizome - chemistry Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology spectral analysis Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology triterpenoid saponins
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Zusammenfassung:	Three new 9,19-cycloartane triterpene glycosides, asiaticoside A (1), asiaticoside B (2), and 25-O-ethylcimigenol-3-O-β-d-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3-β-O-d-xyloside (5), and 25-anhydrocimigenol-β-O-d-xyloside (6) were isolated from the roots/rhizomes extract of Actaea asiatica, and their structures were established by spectroscopic methods (IR, HRESIMS, and NMR). Compounds 1−3, 5, and 6 had notable cytotoxicity against HepG2 and MCF-7 cancer cell lines.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np060113h