Stemoninines from the Roots of Stemona t uberosa

Stemoninines from the Roots of Stemona t uberosa

Five new stemoninine-type alkaloids, bisdehydrostemoninine (1), isobisdehydrostemoninine (2), bisdehydroneostemoninine (3), and bisdehydrostemoninines A (4) and B (5), were isolated from the crude-alkaloid extract of the roots of Stemona tuberosa. Their structures were elucidated on the basis of one...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2006-07, Vol.69 (7), p.1051-1054
Hauptverfasser: Lin, Li-Gen, Zhong, Qiong-Xing, Cheng, Tin-Yan, Tang, Chun-Ping, Ke, Chang-Qiang, Lin, Ge, Ye, Yang
Format: Artikel
Sprache:eng
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Zusammenfassung:Five new stemoninine-type alkaloids, bisdehydrostemoninine (1), isobisdehydrostemoninine (2), bisdehydroneostemoninine (3), and bisdehydrostemoninines A (4) and B (5), were isolated from the crude-alkaloid extract of the roots of Stemona tuberosa. Their structures were elucidated on the basis of one- and two-dimensional NMR and other spectroscopic studies. The relative configuration of 4 was determined by X-ray diffraction. Alkaloid 1 displayed significant antitussive activity in the citric acid-induced guinea pig cough model.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0505317