Cyclohexadepsipeptides from the Insect Pathogenic Fungus Hirsutella n ivea BCC 2594

Two new cyclohexadepsipeptides, hirsutatins A (1) and B (2), were isolated from a culture filtrate of the insect pathogenic fungus Hirsutella nivea BCC 2594. Structures of these compounds were elucidated primarily by NMR and mass spectroscopic analyses. The α-carbon stereochemistry of 1 was establis...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-11, Vol.68 (11), p.1680-1682
Hauptverfasser:	Isaka, Masahiko, Palasarn, Somporn, Sriklung, Kanlayanee, Kocharin, Kanokarn
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Sprache:	eng
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container_title	Journal of natural products (Washington, D.C.)
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creator	Isaka, Masahiko Palasarn, Somporn Sriklung, Kanlayanee Kocharin, Kanokarn
description	Two new cyclohexadepsipeptides, hirsutatins A (1) and B (2), were isolated from a culture filtrate of the insect pathogenic fungus Hirsutella nivea BCC 2594. Structures of these compounds were elucidated primarily by NMR and mass spectroscopic analyses. The α-carbon stereochemistry of 1 was established by HPLC analysis of its acid hydrolysate using a chiral column. Hirsutatin B (2) exhibited activity against the malarial parasite Plasmodium falciparum K1 with an IC50 value of 5.8 μg/mL, while hirsutatin A (1) was inactive at a concentration of 20 μg/mL.
doi_str_mv	10.1021/np050246n
format	Article
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Hirsutatin B (2) exhibited activity against the malarial parasite Plasmodium falciparum K1 with an IC50 value of 5.8 μg/mL, while hirsutatin A (1) was inactive at a concentration of 20 μg/mL.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np050246n</identifier><language>eng</language><publisher>American Chemical Society</publisher><ispartof>Journal of natural products (Washington, D.C.), 2005-11, Vol.68 (11), p.1680-1682</ispartof><rights>Copyright © 2005 American Chemical Society and American Society of Pharmacognosy</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a104n-d9f2c9ec6e1b8f3eff97c050fef6162ff1ab7ede6461eddea07b654219b47a4f3</citedby><cites>FETCH-LOGICAL-a104n-d9f2c9ec6e1b8f3eff97c050fef6162ff1ab7ede6461eddea07b654219b47a4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np050246n$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np050246n$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,781,785,2766,27081,27929,27930,56743,56793</link.rule.ids></links><search><creatorcontrib>Isaka, Masahiko</creatorcontrib><creatorcontrib>Palasarn, Somporn</creatorcontrib><creatorcontrib>Sriklung, Kanlayanee</creatorcontrib><creatorcontrib>Kocharin, Kanokarn</creatorcontrib><title>Cyclohexadepsipeptides from the Insect Pathogenic Fungus Hirsutella n ivea BCC 2594</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. 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Hirsutatin B (2) exhibited activity against the malarial parasite Plasmodium falciparum K1 with an IC50 value of 5.8 μg/mL, while hirsutatin A (1) was inactive at a concentration of 20 μg/mL.</description><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNptkEFLwzAYhoMoOKcH_0EuHjxUv6Rpuhy1ODcYKKjnkqZf1owuLUkr7t9bmXjy9F4eXh4eQq4Z3DHg7N73kAEX0p-QGcs4JBJ4dkpmwGSapAspzslFjDsASEFlM_JWHEzbNfila-yj67EfXI2R2tDt6dAgXfuIZqCvemi6LXpn6HL02zHSlQtxHLBtNfXUfaKmj0VBeabEJTmzuo149btz8rF8ei9WyebleV08bBLNQPikVpYbhUYiqxY2RWtVbiZ7i1Yyya1lusqxRikkw7pGDXklM8GZqkSuhU3n5Pb4a0IXY0Bb9sHtdTiUDMqfGuVfjYm9ObLaxHLXjcFPZv9w34PdXxA</recordid><startdate>20051128</startdate><enddate>20051128</enddate><creator>Isaka, Masahiko</creator><creator>Palasarn, Somporn</creator><creator>Sriklung, Kanlayanee</creator><creator>Kocharin, Kanokarn</creator><general>American Chemical Society</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20051128</creationdate><title>Cyclohexadepsipeptides from the Insect Pathogenic Fungus Hirsutella n ivea BCC 2594</title><author>Isaka, Masahiko ; Palasarn, Somporn ; Sriklung, Kanlayanee ; Kocharin, Kanokarn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a104n-d9f2c9ec6e1b8f3eff97c050fef6162ff1ab7ede6461eddea07b654219b47a4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Isaka, Masahiko</creatorcontrib><creatorcontrib>Palasarn, Somporn</creatorcontrib><creatorcontrib>Sriklung, Kanlayanee</creatorcontrib><creatorcontrib>Kocharin, Kanokarn</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Isaka, Masahiko</au><au>Palasarn, Somporn</au><au>Sriklung, Kanlayanee</au><au>Kocharin, Kanokarn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclohexadepsipeptides from the Insect Pathogenic Fungus Hirsutella n ivea BCC 2594</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2005-11-28</date><risdate>2005</risdate><volume>68</volume><issue>11</issue><spage>1680</spage><epage>1682</epage><pages>1680-1682</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><abstract>Two new cyclohexadepsipeptides, hirsutatins A (1) and B (2), were isolated from a culture filtrate of the insect pathogenic fungus Hirsutella nivea BCC 2594. Structures of these compounds were elucidated primarily by NMR and mass spectroscopic analyses. The α-carbon stereochemistry of 1 was established by HPLC analysis of its acid hydrolysate using a chiral column. Hirsutatin B (2) exhibited activity against the malarial parasite Plasmodium falciparum K1 with an IC50 value of 5.8 μg/mL, while hirsutatin A (1) was inactive at a concentration of 20 μg/mL.</abstract><pub>American Chemical Society</pub><doi>10.1021/np050246n</doi><tpages>3</tpages></addata></record>
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title	Cyclohexadepsipeptides from the Insect Pathogenic Fungus Hirsutella n ivea BCC 2594
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