Characterization of the Preferred Stereochemistry for the Neuropharmacologic Actions of Antillatoxin

Antillatoxin is a potent ichthyotoxin and cytotoxin previously discovered from the marine cyanobacterium Lyngbya majuscula. Ensuing studies of its mechanism of action showed it to activate the mammalian voltage-gated sodium channel at a pharmacological site that is distinct from any previously descr...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-04, Vol.67 (4), p.559-568
Hauptverfasser:	Li, W. I, Marquez, B. L, Okino, T, Yokokawa, F, Shioiri, T, Gerwick, W. H, Murray, T. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriology Biological and medical sciences Cell Survival - drug effects Cells, Cultured Cerebellum - cytology Cerebellum - physiology Crystallography, X-Ray Cyanobacteria - chemistry Fundamental and applied biological sciences. Psychology Goldfish - metabolism Lipopeptides Lyngbya Toxins - pharmacology Marine Toxins - pharmacology Mice Microbiology Models, Molecular Molecular Structure Neurons - drug effects Neurons - physiology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Peptides, Cyclic - pharmacology Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - metabolism Sodium Channels - drug effects Sodium Channels - physiology Stereoisomerism
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