Bioactive Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella g lobostellata
Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A−D (3−6), (−)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellett...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2002-02, Vol.65 (2), p.210-214 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 65 |
| creator | Tasdemir, Deniz Mangalindan, Gina C Concepción, Gisela P Verbitski, Sheryl M Rabindran, Sridhar Miranda, Miriam Greenstein, Michael Hooper, John N. A Harper, Mary Kay Ireland, Chris M |
| description | Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A−D (3−6), (−)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (−)-stellettin E (7) showed selective cytotoxicity toward p21WAF1/Cip1-deficient human colon tumor (HCT-116) cells with IC50 values of 0.043 and 0.039 μM, respectively. |
| doi_str_mv | 10.1021/np0104020 |
| format | Article |
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Stellettin B (4) and (−)-stellettin E (7) showed selective cytotoxicity toward p21WAF1/Cip1-deficient human colon tumor (HCT-116) cells with IC50 values of 0.043 and 0.039 μM, respectively.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np0104020</identifier><language>eng</language><publisher>American Chemical Society</publisher><ispartof>Journal of natural products (Washington, D.C.), 2002-02, Vol.65 (2), p.210-214</ispartof><rights>Copyright © 2002 American Chemical Society and American Society of Pharmacognosy</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a1040-8a6ae7c404158e06b11426702dd134d79e63251530bea86e94fefaf94a90c9ab3</citedby><cites>FETCH-LOGICAL-a1040-8a6ae7c404158e06b11426702dd134d79e63251530bea86e94fefaf94a90c9ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np0104020$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np0104020$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,782,786,2769,27085,27933,27934,56747,56797</link.rule.ids></links><search><creatorcontrib>Tasdemir, Deniz</creatorcontrib><creatorcontrib>Mangalindan, Gina C</creatorcontrib><creatorcontrib>Concepción, Gisela P</creatorcontrib><creatorcontrib>Verbitski, Sheryl M</creatorcontrib><creatorcontrib>Rabindran, Sridhar</creatorcontrib><creatorcontrib>Miranda, Miriam</creatorcontrib><creatorcontrib>Greenstein, Michael</creatorcontrib><creatorcontrib>Hooper, John N. 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Stellettin B (4) and (−)-stellettin E (7) showed selective cytotoxicity toward p21WAF1/Cip1-deficient human colon tumor (HCT-116) cells with IC50 values of 0.043 and 0.039 μM, respectively.</description><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNptkE9Lw0AUxBdRMFYPfoO9ePAQffsnm-SoxWqhImg9eAovm5c2Jc2G3Sj47U2oePI0DPNjGIaxSwE3AqS47XoQoEHCEYtEIiE2IJNjFoEwKlaZ0afsLIQdACjIk4h93DcO7dB8EV8Gt8cWS_SNxY742jcD-Z46Crz2bs-HLfHnMR2zt951G-KvWywrDIOntkW-4a0rXRgmM-A5O6mxDXTxqzP2vnhYz5_i1cvjcn63inEaGmdokFKrQYskIzClEFqaFGRVCaWrNCejZCISBSVhZijXNdVY5xpzsDmWasauD73WuxA81UXvmz3670JAMX1S_H0yslcHFm0odu7Td-Oyf7gfzQNgIA</recordid><startdate>20020222</startdate><enddate>20020222</enddate><creator>Tasdemir, Deniz</creator><creator>Mangalindan, Gina C</creator><creator>Concepción, Gisela P</creator><creator>Verbitski, Sheryl M</creator><creator>Rabindran, Sridhar</creator><creator>Miranda, Miriam</creator><creator>Greenstein, Michael</creator><creator>Hooper, John N. 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Prod</addtitle><date>2002-02-22</date><risdate>2002</risdate><volume>65</volume><issue>2</issue><spage>210</spage><epage>214</epage><pages>210-214</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><abstract>Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A−D (3−6), (−)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (−)-stellettin E (7) showed selective cytotoxicity toward p21WAF1/Cip1-deficient human colon tumor (HCT-116) cells with IC50 values of 0.043 and 0.039 μM, respectively.</abstract><pub>American Chemical Society</pub><doi>10.1021/np0104020</doi><tpages>5</tpages></addata></record> |
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| title | Bioactive Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella g lobostellata |
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