Bioactive Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella g lobostellata

Bioactive Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella g lobostellata

Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A−D (3−6), (−)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellett...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2002-02, Vol.65 (2), p.210-214
Hauptverfasser: Tasdemir, Deniz, Mangalindan, Gina C, Concepción, Gisela P, Verbitski, Sheryl M, Rabindran, Sridhar, Miranda, Miriam, Greenstein, Michael, Hooper, John N. A, Harper, Mary Kay, Ireland, Chris M
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Sprache:eng
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Zusammenfassung:Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A−D (3−6), (−)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (−)-stellettin E (7) showed selective cytotoxicity toward p21WAF1/Cip1-deficient human colon tumor (HCT-116) cells with IC50 values of 0.043 and 0.039 μM, respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0104020