The Differential Cytotoxicity of Water-Soluble Fullerenes
We show that the cytotoxicity of water-soluble fullerene species is a sensitive function of surface derivatization; in two different human cell lines, the lethal dose of fullerene changed over 7 orders of magnitude with relatively minor alterations in fullerene structure. In particular, an aggregate...
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| Veröffentlicht in: | Nano letters 2004-10, Vol.4 (10), p.1881-1887 |
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| container_issue | 10 |
| container_start_page | 1881 |
| container_title | Nano letters |
| container_volume | 4 |
| creator | Sayes, Christie M Fortner, John D Guo, Wenh Lyon, Delina Boyd, Adina M Ausman, Kevin D Tao, Yizhi J Sitharaman, Balaji Wilson, Lon J Hughes, Joseph B West, Jennifer L Colvin, Vicki L |
| description | We show that the cytotoxicity of water-soluble fullerene species is a sensitive function of surface derivatization; in two different human cell lines, the lethal dose of fullerene changed over 7 orders of magnitude with relatively minor alterations in fullerene structure. In particular, an aggregated form of C60, the least derivatized of the four materials, was substantially more toxic than highly soluble derivatives such as C3, Na+ 2 - 3[C60O7 - 9(OH)12 - 15](2-3)-, and C60(OH)24. Oxidative damage to the cell membranes was observed in all cases where fullerene exposure led to cell death. We show that under ambient conditions in water fullerenes can generate superoxide anions and postulate that these oxygen radicals are responsible for membrane damage and subsequent cell death. This work demonstrates both a strategy for enhancing the toxicity of fullerenes for certain applications such as cancer therapeutics or bactericides, as well as a remediation for the possible unwarranted biological effects of pristine fullerenes. |
| doi_str_mv | 10.1021/nl0489586 |
| format | Article |
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In particular, an aggregated form of C60, the least derivatized of the four materials, was substantially more toxic than highly soluble derivatives such as C3, Na+ 2 - 3[C60O7 - 9(OH)12 - 15](2-3)-, and C60(OH)24. Oxidative damage to the cell membranes was observed in all cases where fullerene exposure led to cell death. We show that under ambient conditions in water fullerenes can generate superoxide anions and postulate that these oxygen radicals are responsible for membrane damage and subsequent cell death. 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Psychology ; General aspects ; Medical sciences ; Membranes, bilayers, and vesicles ; Molecular and cellular biology</subject><ispartof>Nano letters, 2004-10, Vol.4 (10), p.1881-1887</ispartof><rights>Copyright © 2004 American Chemical Society</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a353t-ee55e07ef757a8987b05033ccdd7022f775c14b587334c5f30173b98f733360e3</citedby><cites>FETCH-LOGICAL-a353t-ee55e07ef757a8987b05033ccdd7022f775c14b587334c5f30173b98f733360e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/nl0489586$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/nl0489586$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16214800$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Sayes, Christie M</creatorcontrib><creatorcontrib>Fortner, John D</creatorcontrib><creatorcontrib>Guo, Wenh</creatorcontrib><creatorcontrib>Lyon, Delina</creatorcontrib><creatorcontrib>Boyd, Adina M</creatorcontrib><creatorcontrib>Ausman, Kevin D</creatorcontrib><creatorcontrib>Tao, Yizhi J</creatorcontrib><creatorcontrib>Sitharaman, Balaji</creatorcontrib><creatorcontrib>Wilson, Lon J</creatorcontrib><creatorcontrib>Hughes, Joseph B</creatorcontrib><creatorcontrib>West, Jennifer L</creatorcontrib><creatorcontrib>Colvin, Vicki L</creatorcontrib><title>The Differential Cytotoxicity of Water-Soluble Fullerenes</title><title>Nano letters</title><addtitle>Nano Lett</addtitle><description>We show that the cytotoxicity of water-soluble fullerene species is a sensitive function of surface derivatization; in two different human cell lines, the lethal dose of fullerene changed over 7 orders of magnitude with relatively minor alterations in fullerene structure. In particular, an aggregated form of C60, the least derivatized of the four materials, was substantially more toxic than highly soluble derivatives such as C3, Na+ 2 - 3[C60O7 - 9(OH)12 - 15](2-3)-, and C60(OH)24. Oxidative damage to the cell membranes was observed in all cases where fullerene exposure led to cell death. We show that under ambient conditions in water fullerenes can generate superoxide anions and postulate that these oxygen radicals are responsible for membrane damage and subsequent cell death. This work demonstrates both a strategy for enhancing the toxicity of fullerenes for certain applications such as cancer therapeutics or bactericides, as well as a remediation for the possible unwarranted biological effects of pristine fullerenes.</description><subject>Biological and medical sciences</subject><subject>Cell membranes. Ionic channels. Membrane pores</subject><subject>Cell structures and functions</subject><subject>Diseases</subject><subject>Fundamental and applied biological sciences. 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Ionic channels. Membrane pores</topic><topic>Cell structures and functions</topic><topic>Diseases</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Medical sciences</topic><topic>Membranes, bilayers, and vesicles</topic><topic>Molecular and cellular biology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sayes, Christie M</creatorcontrib><creatorcontrib>Fortner, John D</creatorcontrib><creatorcontrib>Guo, Wenh</creatorcontrib><creatorcontrib>Lyon, Delina</creatorcontrib><creatorcontrib>Boyd, Adina M</creatorcontrib><creatorcontrib>Ausman, Kevin D</creatorcontrib><creatorcontrib>Tao, Yizhi J</creatorcontrib><creatorcontrib>Sitharaman, Balaji</creatorcontrib><creatorcontrib>Wilson, Lon J</creatorcontrib><creatorcontrib>Hughes, Joseph B</creatorcontrib><creatorcontrib>West, Jennifer L</creatorcontrib><creatorcontrib>Colvin, Vicki L</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Nano letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sayes, Christie M</au><au>Fortner, John D</au><au>Guo, Wenh</au><au>Lyon, Delina</au><au>Boyd, Adina M</au><au>Ausman, Kevin D</au><au>Tao, Yizhi J</au><au>Sitharaman, Balaji</au><au>Wilson, Lon J</au><au>Hughes, Joseph B</au><au>West, Jennifer L</au><au>Colvin, Vicki L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Differential Cytotoxicity of Water-Soluble Fullerenes</atitle><jtitle>Nano letters</jtitle><addtitle>Nano Lett</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>4</volume><issue>10</issue><spage>1881</spage><epage>1887</epage><pages>1881-1887</pages><issn>1530-6984</issn><eissn>1530-6992</eissn><abstract>We show that the cytotoxicity of water-soluble fullerene species is a sensitive function of surface derivatization; in two different human cell lines, the lethal dose of fullerene changed over 7 orders of magnitude with relatively minor alterations in fullerene structure. In particular, an aggregated form of C60, the least derivatized of the four materials, was substantially more toxic than highly soluble derivatives such as C3, Na+ 2 - 3[C60O7 - 9(OH)12 - 15](2-3)-, and C60(OH)24. Oxidative damage to the cell membranes was observed in all cases where fullerene exposure led to cell death. We show that under ambient conditions in water fullerenes can generate superoxide anions and postulate that these oxygen radicals are responsible for membrane damage and subsequent cell death. This work demonstrates both a strategy for enhancing the toxicity of fullerenes for certain applications such as cancer therapeutics or bactericides, as well as a remediation for the possible unwarranted biological effects of pristine fullerenes.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><doi>10.1021/nl0489586</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 1530-6984 |
| ispartof | Nano letters, 2004-10, Vol.4 (10), p.1881-1887 |
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| source | American Chemical Society Journals |
| subjects | Biological and medical sciences Cell membranes. Ionic channels. Membrane pores Cell structures and functions Diseases Fundamental and applied biological sciences. Psychology General aspects Medical sciences Membranes, bilayers, and vesicles Molecular and cellular biology |
| title | The Differential Cytotoxicity of Water-Soluble Fullerenes |
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