hERG Classification Model Based on a Combination of Support Vector Machine Method and GRIND Descriptors

The human Ether-a-go-go Related Gene (hERG) potassium channel is one of the major critical factors associated with QT interval prolongation and development of arrhythmia called Torsades de Pointes (TdP). It has become a growing concern of both regulatory agencies and pharmaceutical industries who in...

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Veröffentlicht in:	Molecular pharmaceutics 2008-01, Vol.5 (1), p.117-127
Hauptverfasser:	Li, Qiyuan, Jørgensen, Flemming Steen, Oprea, Tudor, Brunak, Søren, Taboureau, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer Simulation Ether-A-Go-Go Potassium Channels - antagonists & inhibitors Humans Models, Molecular Models, Theoretical Potassium Channel Blockers - pharmacology Quantitative Structure-Activity Relationship Sensitivity and Specificity
Online-Zugang:	Volltext
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