An Anti-B7-H4 Antibody–Drug Conjugate for the Treatment of Breast Cancer

B7-H4 has been implicated in cancers of the female reproductive system and investigated for its possible use as a biomarker for cancer, but there are no preclinical studies to demonstrate that B7-H4 is a molecular target for therapeutic intervention of cancer. We provide evidence that the prevalence...

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Veröffentlicht in:	Molecular pharmaceutics 2015-06, Vol.12 (6), p.1717-1729
Hauptverfasser:	Leong, Steven R, Liang, Wei-Ching, Wu, Yan, Crocker, Lisa, Cheng, Eric, Sampath, Deepak, Ohri, Rachana, Raab, Helga, Hass, Philip E, Pham, Thinh, Firestein, Ron, Li, Dongwei, Schutten, Melissa, Stagg, Nicola J, Ogasawara, Annie, Koppada, Neelima, Roth, Leslie, Williams, Simon P, Lee, Byoung-Chul, Chalouni, Cecile, Peng, Ivan, DeVoss, Jason, Tremayne, Jarrod, Polakis, Paul, Polson, Andrew G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Blotting, Western Cell Line, Tumor Female Flow Cytometry Humans Immunoconjugates - chemistry Immunoconjugates - therapeutic use Immunohistochemistry Mice Mice, SCID Oligopeptides - chemistry Oligopeptides - therapeutic use Rats Rats, Sprague-Dawley Triple Negative Breast Neoplasms - drug therapy Xenograft Model Antitumor Assays
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