Synthesis and Characterization of Thermoresponsive-co-Biodegradable Linear−Dendritic Copolymers

Synthesis and Characterization of Thermoresponsive-co-Biodegradable Linear−Dendritic Copolymers

A novel linear−dendritic copolymer containing thermoresponsive poly(N-isopropylacrylamide) (PNIPAAM), hydrophobic and biodegradable poly(l-lactic acid) (PLLA), and hydrophilic poly(l-lysine) (PLL) dendrons was designed, synthesized and characterized. The thermoresponsive-co-biodegradable linear−dend...

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Veröffentlicht in:Macromolecules 2006-11, Vol.39 (23), p.7805-7811
Hauptverfasser: Kim, Young Shin, Gil, Eun Seok, Lowe, Tao Lu
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Sprache:eng
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Aminoacid polymers
Applied sciences
Exact sciences and technology
Physicochemistry of polymers
Synthetic biopolymers
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container_title Macromolecules
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creator Kim, Young Shin
Gil, Eun Seok
Lowe, Tao Lu
description A novel linear−dendritic copolymer containing thermoresponsive poly(N-isopropylacrylamide) (PNIPAAM), hydrophobic and biodegradable poly(l-lactic acid) (PLLA), and hydrophilic poly(l-lysine) (PLL) dendrons was designed, synthesized and characterized. The thermoresponsive-co-biodegradable linear−dendritic copolymer was synthesized by 1,3-dicyclohexylcarbodiimide (DCC) coupling reaction of three generation PLL dendron and PNIPAAM grafted with PLLA. UV−vis spectroscopy and dynamic light scattering measurements demonstrated that the linear−dendritic copolymer was thermoresponsive by showing a lower critical solution temperature whose value depended on the linear−dendritic copolymer concentrations. The viscosity and molar mass of the linear−dendritic copolymer decreased with time in PBS (pH = 7.4) solutions indicating that the linear−dendritic copolymer is degradable. FTIR measurements further revealed that the degradation of the linear−dendritic copolymer was due to the hydrolytic degradation of the ester bonds of the PLLA component.
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The thermoresponsive-co-biodegradable linear−dendritic copolymer was synthesized by 1,3-dicyclohexylcarbodiimide (DCC) coupling reaction of three generation PLL dendron and PNIPAAM grafted with PLLA. UV−vis spectroscopy and dynamic light scattering measurements demonstrated that the linear−dendritic copolymer was thermoresponsive by showing a lower critical solution temperature whose value depended on the linear−dendritic copolymer concentrations. The viscosity and molar mass of the linear−dendritic copolymer decreased with time in PBS (pH = 7.4) solutions indicating that the linear−dendritic copolymer is degradable. 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subjects Aminoacid polymers
Applied sciences
Exact sciences and technology
Physicochemistry of polymers
Synthetic biopolymers
title Synthesis and Characterization of Thermoresponsive-co-Biodegradable Linear−Dendritic Copolymers
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