DNA Alignment at Cationic Lipid Monolayers at the Air/Water Interface

DNA Alignment at Cationic Lipid Monolayers at the Air/Water Interface

The interaction of DNA with other DNA and with charged interfaces is of utmost importance for understanding nonviral transfection and DNA diagnostics with optimized chips. This can be studied in detail using Langmuir monolayers of cationic lipids as soft surface of a DNA containing subphase. The pos...

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Veröffentlicht in:Macromolecules 2004-05, Vol.37 (10), p.3865-3873
Hauptverfasser: Symietz, Christian, Schneider, Marc, Brezesinski, Gerald, Möhwald, Helmuth
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Sprache:eng
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Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Interactions. Associations
Intermolecular phenomena
Molecular biophysics
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container_end_page 3873
container_issue 10
container_start_page 3865
container_title Macromolecules
container_volume 37
creator Symietz, Christian
Schneider, Marc
Brezesinski, Gerald
Möhwald, Helmuth
description The interaction of DNA with other DNA and with charged interfaces is of utmost importance for understanding nonviral transfection and DNA diagnostics with optimized chips. This can be studied in detail using Langmuir monolayers of cationic lipids as soft surface of a DNA containing subphase. The positional order of the lipid and the DNA sublattices can be studied by synchrotron X-ray diffraction under continuous variation of parameters such as molecular density or surface pressure. It is shown that DNA binding condenses the membrane surface, and the resulting structure is determined by the interplay of DNA−lipid and DNA−DNA interactions.
doi_str_mv 10.1021/ma0348425
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subjects Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Interactions. Associations
Intermolecular phenomena
Molecular biophysics
title DNA Alignment at Cationic Lipid Monolayers at the Air/Water Interface
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