Surface Imprinting of Cholesterol on Submicrometer Core−Shell Emulsion Particles

Surface Imprinting of Cholesterol on Submicrometer Core−Shell Emulsion Particles

Submicrometer surface-imprinted particles were prepared by a two-stage aqueous emulsion polymerization with a poly(divinylbenzene) shell over a cross-linked poly(styrene) core. The second stage polymerization was performed in the presence of a polymerizable surfactant (pyridinium 12-(4-vinylbenzylox...

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Veröffentlicht in:Macromolecules 2001-02, Vol.34 (4), p.830-836
Hauptverfasser: Pérez, Natalia, Whitcombe, Michael J, Vulfson, Evgeny N
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Sprache:eng
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Applied sciences
Exact sciences and technology
Organic polymers
Physicochemistry of polymers
Polymerization
Preparation, kinetics, thermodynamics, mechanism and catalysts
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container_title Macromolecules
container_volume 34
creator Pérez, Natalia
Whitcombe, Michael J
Vulfson, Evgeny N
description Submicrometer surface-imprinted particles were prepared by a two-stage aqueous emulsion polymerization with a poly(divinylbenzene) shell over a cross-linked poly(styrene) core. The second stage polymerization was performed in the presence of a polymerizable surfactant (pyridinium 12-(4-vinylbenzyloxycarbonyl)dodecanesulfate, PS) and pyridinium 12-(cholesteryloxycarbonyloxy)dodecanesulfate (TS), which acted both as a surfactant and as a template. Removal of the template left hydrophobic cavities on the surface of charged particles or particles bearing benzyl alcohol groups, dependent on the protocol adopted. Particles were shown to rebind cholesterol in 60% 2-propanol in water, and a poly(ethylene glycol) (PEG) modified with cholesterol at both chain ends was capable of flocculating the imprinted particles. No flocculation was seen either when a monocholesteryl PEG was used or when nonimprinted particles were used.
doi_str_mv 10.1021/ma001079v
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subjects Applied sciences
Exact sciences and technology
Organic polymers
Physicochemistry of polymers
Polymerization
Preparation, kinetics, thermodynamics, mechanism and catalysts
title Surface Imprinting of Cholesterol on Submicrometer Core−Shell Emulsion Particles
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