Fluorescence Turn On by Cholate Aggregates
Bile salts, including sodium cholate (NaCh), are amphiphilic molecules with a concave hydrophilic side and a convex hydrophobic side. By forming aggregates in aqueous solution, these natural surfactants fulfill vital biological roles in the solubilization of cholesterol, lipids, and fat-soluble vita...
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| Veröffentlicht in: | Langmuir 2011-04, Vol.27 (7), p.3271-3274 |
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| creator | Baldridge, Anthony Amador, Adrian Tolbert, Laren M |
| description | Bile salts, including sodium cholate (NaCh), are amphiphilic molecules with a concave hydrophilic side and a convex hydrophobic side. By forming aggregates in aqueous solution, these natural surfactants fulfill vital biological roles in the solubilization of cholesterol, lipids, and fat-soluble vitamins and thus are involved in the transport and absorption of important biological molecules. Following our success with the encapsulation of fluorescent protein chromophore (FP) analogs by synthetic hydrophobic and hydrophilic hosts, based upon substitution patterns, we now report the binding and turn on of other analogs by bile salt aggregates, observations which may lead to new tools for studying trafficking in these important systems. |
| doi_str_mv | 10.1021/la2003244 |
| format | Article |
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| ispartof | Langmuir, 2011-04, Vol.27 (7), p.3271-3274 |
| issn | 0743-7463 1520-5827 |
| language | eng |
| recordid | cdi_crossref_primary_10_1021_la2003244 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Bile Acids and Salts - chemistry Chemistry Cholates - chemistry Exact sciences and technology Fluorescence General and physical chemistry Hydrophobic and Hydrophilic Interactions Models, Molecular Molecular Structure Sodium Cholate - chemistry |
| title | Fluorescence Turn On by Cholate Aggregates |
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