Current Perspectives on Pain upon Injection of Drugs
A limitation in the administration of parenteral products is the pain caused upon injection. Injection site pain has been predominately associated with intravenous, intramuscular, and subcutaneous administration. It becomes important for the formulation scientist to have a basic understanding of the...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1998-06, Vol.87 (6), p.667-677 |
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| container_end_page | 677 |
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| container_issue | 6 |
| container_start_page | 667 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 87 |
| creator | Brazeau, Gayle A. Cooper, Brian Svetic, Kari A. Smith, Charles L. Gupta, Pramod |
| description | A limitation in the administration of parenteral products is the pain caused upon injection. Injection site pain has been predominately associated with intravenous, intramuscular, and subcutaneous administration. It becomes important for the formulation scientist to have a basic understanding of the physiology underlying the pain process, as well as the pharmaceutical factors associated with injection site pain. Initially, this review will provide the reader with a primer on the mediation of pain in the periphery and a compilation of those drugs that have been associated with pain on injection. In addition, this review will present important considerations and general formulation approaches or methods that have been used to overcome pain on injection. Finally, a brief overview of the various experimental systems used to investigate injection site pain is discussed |
| doi_str_mv | 10.1021/js970315l |
| format | Article |
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Pharm. Sci</addtitle><description>A limitation in the administration of parenteral products is the pain caused upon injection. Injection site pain has been predominately associated with intravenous, intramuscular, and subcutaneous administration. It becomes important for the formulation scientist to have a basic understanding of the physiology underlying the pain process, as well as the pharmaceutical factors associated with injection site pain. Initially, this review will provide the reader with a primer on the mediation of pain in the periphery and a compilation of those drugs that have been associated with pain on injection. In addition, this review will present important considerations and general formulation approaches or methods that have been used to overcome pain on injection. Finally, a brief overview of the various experimental systems used to investigate injection site pain is discussed</description><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Humans</subject><subject>Injections - adverse effects</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pain - etiology</subject><subject>Pharmacology. 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Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brazeau, Gayle A.</creatorcontrib><creatorcontrib>Cooper, Brian</creatorcontrib><creatorcontrib>Svetic, Kari A.</creatorcontrib><creatorcontrib>Smith, Charles L.</creatorcontrib><creatorcontrib>Gupta, Pramod</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brazeau, Gayle A.</au><au>Cooper, Brian</au><au>Svetic, Kari A.</au><au>Smith, Charles L.</au><au>Gupta, Pramod</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current Perspectives on Pain upon Injection of Drugs</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. 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Finally, a brief overview of the various experimental systems used to investigate injection site pain is discussed</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>9607942</pmid><doi>10.1021/js970315l</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1998-06, Vol.87 (6), p.667-677 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Drug toxicity and drugs side effects treatment Humans Injections - adverse effects Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pain - etiology Pharmacology. Drug treatments |
| title | Current Perspectives on Pain upon Injection of Drugs |
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