Solution Phase Combinatorial Chemistry. Synthesis of Novel Linear Pyridinopolyamine Libraries with Potent Antibacterial Activity

Novel linear pyridinopolyamine derivatives 1−3, 7, and 8 have been synthesized as scaffolds for combinatorial drug discovery. The mono-t-Boc- and monotosyl-protected linear scaffolds 1 and 2 were obtained by a Schiff base type cyclization of 2,6-pyridinedicarboxaldehyde (24) with monoprotected triam...

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Veröffentlicht in:	Journal of organic chemistry 1997-07, Vol.62 (15), p.5156-5164
Hauptverfasser:	An, Haoyun, Haly, Becky D, Fraser, Allister S, Guinosso, Charles J, Cook, P. Dan
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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