Choosing the Right Reagent for the Determination of the Absolute Configuration of Amines by NMR:  MTPA or MPA?

Molecular mechanics, semiempirical (AM1), aromatic shielding effect calculations, and dynamic NMR experiments demonstrate that MTPA amides are constituted by three main conformers, sp, ap3, and ap1 due to restricted rotation around the Cα−CO and the Cα−Ph bonds. Unlike MTPA esters, where the three r...

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Veröffentlicht in:	Journal of organic chemistry 1997-10, Vol.62 (22), p.7569-7574
Hauptverfasser:	Seco, J. M, Latypov, Sh. K, Quiñoá, E, Riguera, R
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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