Pd(0)/Cu(I)-Mediated Direct Arylation of 2′-Deoxyadenosines: Mechanistic Role of Cu(I) and Reactivity Comparisons with Related Purine Nucleosides

Pd/Cu-mediated direct arylation of 2′-deoxyadenosine with various aryl iodides provides 8-arylated 2′-deoxyadenosine derivatives in good yields. Following significant reaction optimization, it has been determined that a substoichiometric quantity of piperidine (secondary amine) in combination with c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2009-08, Vol.74 (16), p.5810-5821
Hauptverfasser:	Storr, Thomas E, Baumann, Christoph G, Thatcher, Robert J, De Ornellas, Sara, Whitwood, Adrian C, Fairlamb, Ian J. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Carbohydrates. Nucleosides and nucleotides Catalysis Chemical reactivity Chemistry Copper - chemistry Crystallography, X-Ray Deoxyadenosines - chemistry Exact sciences and technology Iodobenzenes - chemistry Kinetics and mechanisms Magnetic Resonance Spectroscopy Models, Molecular Molecular Conformation Nucleosides, nucleotides and oligonucleotides Organic chemistry Palladium - chemistry Preparations and properties Reactivity and mechanisms
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!