Concerning the Hydrolytic Stability of 8-Aryl-2′-deoxyguanosine Nucleoside Adducts: Implications for Abasic Site Formation at Physiological pH

Direct addition of aryl radical species to the C8-site of 2′-deoxyguanosine (dG) affords C8-aryl-dG adducts that are produced by carcinogenic arylhydrazines, polycyclic aromatic hydrocarbons (PAHs), and certain phenolic toxins. A common property of C8-arylpurine adduction is the accompaniment of aba...

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Veröffentlicht in:	Journal of organic chemistry 2009-08, Vol.74 (16), p.5793-5802
Hauptverfasser:	Schlitt, Katherine M, Sun, Ke-wen M, Paugh, Robert J, Millen, Andrea L, Navarro-Whyte, Lex, Wetmore, Stacey D, Manderville, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbohydrates. Nucleosides and nucleotides Chemistry Deoxyguanosine - chemistry DNA Adducts - chemistry Exact sciences and technology Hydrogen-Ion Concentration Hydrolysis Kinetics Models, Molecular Molecular Conformation Nucleosides, nucleotides and oligonucleotides Organic chemistry Preparations and properties Quantum Theory Stereoisomerism
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