Synthetic Approaches to Indolo[6,7-a]pyrrolo[3,4-c]carbazoles:  Potent Cyclin D1/CDK4 Inhibitors

Synthesis of indolo[6,7-a]pyrrolo[3,4-c]carbazoles 1, a new class of cyclin D1/CDK4 inhibitors, by oxidation of the corresponding aryl indolylmaleimides 2, will be described. Two approaches to the synthesis of 2 were identified that required new methods for the synthesis of 7-substituted indole acet...

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