Synthesis of Macrocyclic, Potential Protease Inhibitors Using a Generic Scaffold

A generic macrocyclic peptide structure 2 was designed as a potential inhibitor of a range of proteinases, by using as a basis for the design the known structures of a series of enzyme−inhibitor complexes. The macrocyclic nature of the target 2 was chosen so as to reduce the entropic advantage in th...

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