An Efficient Route for the Preparation of a 21-Fluoro Progestin-16α,17α-Dioxolane, a High-Affinity Ligand for PET Imaging of the Progesterone Receptor

Two different synthetic routes were explored for the synthesis of fluoro furanyl norprogesterone (FFNP) 1, a high-affinity ligand for the progesterone receptor (PgR) that is being developed as a PET imaging agent for PgR-positive breast cancer. Both approaches proceed through a key intermediate, tri...

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Veröffentlicht in:	Journal of organic chemistry 2002-07, Vol.67 (14), p.4904-4910
Hauptverfasser:	Vijaykumar, Dange, Mao, Wang, Kirschbaum, Karen S, Katzenellenbogen, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds, terpenoids, prostaglandins, steroids Chemistry Exact sciences and technology Organic chemistry Preparations and properties Steroids
Online-Zugang:	Volltext
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