First Total Synthesis of Phenylpyridine Analogues of the Antimitotic Rhazinilam

The first synthesis of phenylpyridine analogues of rhazinilam and evaluation of these new structures as inhibitors of microtubule disassembly by interaction with tubulin are described. The synthesis is based on such key steps as picolinic metalation, hetero-ring cross-coupling and reduction of an ac...

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Veröffentlicht in:	Journal of organic chemistry 2001-04, Vol.66 (8), p.2654-2661
Hauptverfasser:	Pasquinet, Eric, Rocca, Patrick, Richalot, Sébastien, Guéritte, Françoise, Guénard, Daniel, Godard, Alain, Marsais, Francis, Quéguiner, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemical synthesis Alkaloids - pharmacology Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Humans Indolizines Inhibitory Concentration 50 Lactams Microtubules - drug effects Pyridines - chemical synthesis Pyridines - pharmacology Stereoisomerism Tubulin Modulators
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