Synthesis and Activities of Pyoverdin−Quinolone Adducts: A Prospective Approach to a Specific Therapy Against Pseudomonas a eruginosa

Pseudomonas aeruginosa is particularly resistant to most all the antibiotics presently available, essentially because of the very low permeability of its outer membrane. To overcome this, we synthesized four siderophore-based antibiotics formed by two quinolones − norfloxacin and benzonaphthyridone...

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Veröffentlicht in:	Journal of medicinal chemistry 2001-06, Vol.44 (13), p.2139-2151
Hauptverfasser:	Hennard, Christophe, Truong, Que Chi, Desnottes, Jean-François, Paris, Jean-Marc, Moreau, Nicole J, Abdallah, Mohamed A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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