Effect of Aromatic Short-Chain Analogues of Ceramide on Axonal Growth in Hippocampal Neurons

A series of d-erythro- and l-threo-ceramide analogues was synthesized and investigated for their ability to reverse the inhibitory effects of fumonisin B1 (FB1) on axonal growth in hippocampal neurons. The analogues contained either a C7 side chain or a phenyl group substituted for the C13 residue p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1999-07, Vol.42 (14), p.2697-2705
Hauptverfasser:	Van Overmeire, Ilse, Boldin, Swetlana A, Dumont, Filip, Van Calenbergh, Serge, Slegers, Guido, De Keukeleire, Denis, Futerman, Anthony H, Herdewijn, Piet
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - drug effects Axons - physiology Biological and medical sciences Carboxylic Acids - antagonists & inhibitors Carboxylic Acids - pharmacology Cells, Cultured Ceramides - chemical synthesis Ceramides - chemistry Ceramides - pharmacology Fumonisins Hippocampus - cytology Hippocampus - drug effects Hippocampus - ultrastructure Medical sciences Miscellaneous Mycotoxins - antagonists & inhibitors Mycotoxins - pharmacology Neurons - drug effects Neurons - physiology Neurons - ultrastructure Neuropharmacology Pharmacology. Drug treatments Rats Rats, Wistar Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!