Alkoxypsoralens, Novel Nonpeptide Blockers of Shaker-Type K+ Channels: Synthesis and Photoreactivity

A series of psoralens and structurally related 5,7-disubstituted coumarins was synthesized and investigated for their K+ channel blocking activity as well as for their phototoxicity to Artemia salina and their ability to generate singlet oxygen and to photomodify DNA. After screening the compounds o...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-11, Vol.41 (23), p.4542-4549
Hauptverfasser:	Wulff, Heike, Rauer, Heiko, Düring, Tim, Hanselmann, Christine, Ruff, Katharina, Wrisch, Anja, Grissmer, Stephan, Hänsel, Wolfram
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Artemia - drug effects Artemia - radiation effects Axons - drug effects Biological and medical sciences Coumarins - chemical synthesis Coumarins - pharmacology Coumarins - toxicity DNA - drug effects DNA - metabolism DNA - radiation effects Drug Evaluation, Preclinical Furocoumarins - chemical synthesis Furocoumarins - pharmacology Furocoumarins - toxicity In Vitro Techniques Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Oxygen - metabolism Oxygen - radiation effects Pharmacology. Drug treatments Potassium Channel Blockers Potassium Channels Ranvier's Nodes - drug effects Ranvier's Nodes - ultrastructure Shaker Superfamily of Potassium Channels Ultraviolet Rays Xenopus laevis
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