New Azole Antifungals. 3. Synthesis and Antifungal Activity of 3-Substituted-4(3H)-quinazolinones

A series of azole antifungal agents featuring a quinazolinone nucleus have been subjected to studies of structure−activity relationships. In general, these compounds displayed higher in vitro activities against filamentous fungi and shorter half-lives than the structures described in our preceding p...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-05, Vol.41 (11), p.1869-1882
Hauptverfasser:	Bartroli, Javier, Turmo, Enric, Algueró, Mònica, Boncompte, Eulàlia, Vericat, Maria L, Conte, Lourdes, Ramis, Joaquim, Merlos, Manuel, García-Rafanell, Julián, Forn, Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacokinetics Antifungal Agents - pharmacology Aspergillosis - drug therapy Aspergillus fumigatus Biological and medical sciences Candidiasis - drug therapy Colony Count, Microbial Fungi - drug effects Fungi - growth & development Male Medical sciences Mice Molecular Conformation Pharmacology. Drug treatments Quinazolines - chemical synthesis Quinazolines - chemistry Quinazolines - pharmacokinetics Quinazolines - pharmacology Rabbits Rats Rats, Sprague-Dawley Stereoisomerism Structure-Activity Relationship Triazoles - chemical synthesis Triazoles - chemistry Triazoles - pharmacokinetics Triazoles - pharmacology
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