Synthesis of a Methylenebis(phosphonate) Analogue of Mycophenolic Adenine Dinucleotide: A Glucuronidation-Resistant MAD Analogue of NAD

Mycophenolic alcohol (MPAlc), obtained by reduction of the carboxylic group of mycophenolic acid (MPA), was coupled with 2‘,3‘-O-isopropylideneadenosine 5‘-methylenebis(phosphonate) (4) in the presence of diisopropylcarbodiimide (DIC) to give P -(2‘,3‘-O-isopropylideneadenosin-5‘-yl)-P -(mycophenoli...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-02, Vol.41 (4), p.618-622
Hauptverfasser:	Lesiak, Krystyna, Watanabe, Kyoichi A, Majumdar, Alokes, Powell, James, Seidman, Michael, Vanderveen, Kristen, Goldstein, Barry M, Pankiewicz, Krzysztof W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotides Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Biological and medical sciences Biotransformation Cell Division - drug effects General aspects Glucuronates Glucuronosyltransferase - metabolism Humans IMP Dehydrogenase - antagonists & inhibitors Indicators and Reagents Medical sciences Molecular Structure Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - chemical synthesis Mycophenolic Acid - chemistry Mycophenolic Acid - pharmacology Mycophenolic Acid - toxicity NAD - analogs & derivatives Pharmacology. Drug treatments Structure-Activity Relationship Tumor Cells, Cultured
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