Synthesis and Anticonvulsant Activity of a New Class of 2-[(Arylalkyl)amino]alkanamide Derivatives

Although most epilepsies are adequately treated by conventional antiepileptic therapy, there remains an unfulfilled need for safer and more effective anticonvulsant agents. Starting from milacemide, a weak anticonvulsant, and trying to elucidate its mechanism of action, we discovered a structurally...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-02, Vol.41 (4), p.579-590
Hauptverfasser:	Pevarello, Paolo, Bonsignori, Alberto, Dostert, Philippe, Heidempergher, Franco, Pinciroli, Vittorio, Colombo, Maristella, McArthur, Robert A, Salvati, Patricia, Post, Claes, Fariello, Ruggero G, Varasi, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Alanine - chemical synthesis Alanine - chemistry Alanine - pharmacology Animals Anticonvulsants - chemical synthesis Anticonvulsants - chemistry Anticonvulsants - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Benzylamines - chemical synthesis Benzylamines - chemistry Benzylamines - pharmacology Bicuculline Biological and medical sciences Drug Design Electroshock Indicators and Reagents Male Medical sciences Mice Mice, Inbred ICR Models, Molecular Molecular Structure Motor Activity - drug effects Neuropharmacology Pharmacology. Drug treatments Picrotoxin Postural Balance - drug effects Postural Balance - physiology Rats Rats, Inbred Strains Seizures - chemically induced Seizures - etiology Seizures - prevention & control Structure-Activity Relationship Strychnine
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